GASTRORETENTIVE DRUG DELIVERY: Floating Matrix Tablets - Brossura

Negi, Jeetendra Singh; Thakur, Vinay; Negi, Vandana

Brossura

ISBN 10: 3843385262 ISBN 13: 9783843385268

Casa editrice: LAP LAMBERT Academic Publishing, 2010

Riassunto

The present project concerns the development of once-daily floating matrix tablets, which after oral administration show prolonged gastric residence and extended release of drug. The asymmetric screening matrix, a D-optimal design, was used for finding out the significant formulation factors. Tablets were obtained by wet granulation of drug with HPMC K100M and various excipients, followed by compression and were evaluated for buoyancy lag time,Q 6h,Q 24h and floating duration, during screening study. The graphical analysis of coefficients was done to find out significant factors. The response surface modeling (RSM) was performed with significant factors obtained from screening study.The D-optimal design was used for RSM and various prediction plots and contour plots were used for RSM. The desirability function was used to combine all the responses for optimization. The Nelder-Mead simplex method was applied for optimization of formulation. The optimized formulation was evaluated for diff. parameters and compared with marketed formulation.Various model dependent and model independent drug release parameters of optimized formulation were comparable to that of marketed formulation.

Su questo libro

L'autore:

Mr. J. Negi, has completed his post Graduation in Pharmaceutics specialization. He published research articles and abstracts in various journals and conferences.

Su questa edizione

• Editore: LAP LAMBERT Academic Publishing
• Data di pubblicazione: 2010
• ISBN 10: 3843385262
• ISBN 13: 9783843385268
• Rilegatura: Copertina flessibile
• Numero di pagine: 132