Formulation of Self Microemulsifying Drug Delivery System: SMEDDS of Antibiotic - Brossura

Mohite, Popat; Harischandre, Vinayak

 
9786202058360: Formulation of Self Microemulsifying Drug Delivery System: SMEDDS of Antibiotic
Brossura
ISBN 10: 6202058366 ISBN 13: 9786202058360
Casa editrice: LAP LAMBERT Academic Publishing, 2017

Sinossi

In this book, a method to prepare self-microemulsifying drug delivery system (SMEDDS) of the poorly water-soluble drugcefadroxil monohydrate is explained. The impact of the oil, surfactant and co-surfactant on the drug solubility and their ratios on forming efficient and stable SMEDDS were examined. Water titration method was used to formulation of SMEDDS. The SMEDDS were characterized by morphological observation, globule size, cloud point measurement,viscosity determination,refractive index,% transmittance, drug content of SMEDDS of cefadroxil monohydrate and in vitro release study. The optimum formulation F2 consisted of oleic acid, tween-80 and PEG-400 with S mix. ratio of 1:1. In vitro release test showed a complete release of cefadroxil monohydrate from SMEDDS in an approximately 1.5hr. SMEDDS cefadroxil monohydrate oral formulations were prepared that provide excellent drug solubilization and improved in vitro release of cefadroxil monohydrate compare to marked product. The selected formulation F2 was tested for pharmacokinetic studies in comparison to marketed formulation it showed increase in the oral bioavailability of cefadroxil monohydrate.

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Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2017
Lingua
Inglese
ISBN 10 
6202058366
ISBN 13 
9786202058360
Rilegatura
Copertina flessibile
Numero di pagine
108
Contatto del produttore
non disponibile
Persona responsabile
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