alexander hillisch (57 risultati)

Hardcover. Condizione: Très bon. Ancien livre de bibliothèque avec équipements. Edition 2002. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Edition 2002. Ammareal gives back up to 15% of this item's net price to charity organizations.

Condizione: New. pp. 301.

Condizione: New. Brand New. Soft Cover International Edition. Different ISBN and Cover Image. Priced lower than the standard editions which is usually intended to make them more affordable for students abroad. The core content of the book is generally the same as the standard edition. The country selling restrictions may be printed on the book but is no problem for the self-use. This Item maybe shipped from US or any other country as we have multiple locations worldwide.

Condizione: Brand New. New.SoftCover International edition. Different ISBN and Cover image but contents are same as US edition.Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

Hardcover. Condizione: Near Fine. 376436081X. Ex library, laminated, pictorial board hardcover. 292 pages, index, illustrated with charts, tables and diagrams. A modern approach to drug discovery as used by pharmaceutical companies and research institutes. It comprehensively covers proteomics, bioinformatics, screening techniques such as high-throughput-, natural compounds-, and NMR-based-screenings, combinatorial chemistry, compound library design, ligand- and structure-based drug design and pharmacokinetic approaches. Each chapter reviews the theory, background and application of a key technology in drug discovery, complemented by an extensive list of references to the original literature. For researchers, in industry and academia, students of pharmaceutical and computational chemistry, bioinformatics, biochemistry, molecular biology and pharmacology. Contents as new, clean, tight and bright. Book.

Condizione: Good. Volume 93. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. Clean from markings. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,900grams, ISBN:9783764360818.

Condizione: Wie neu. XVI, 209 Seiten. Mit 40 Abbildungen. Tadellos erhaltenes Exemplar. / As new. ISBN: 3540402500 Sprache: Englisch Gewicht in Gramm: 990 8° (17,5-22,5 cm). Orig.-Pappband. [Hardcover / fest gebunden].

Hardcover. Condizione: Sehr gut. Zustand: SEHR GUTER Zustand! HC1-209-4/8-00491017 Sprache: Englisch Gewicht in Gramm: 434.

Condizione: New. In.

Hardcover 22x15. Condizione: Gut. 209 Seiten In englischer Sprache/ English. Sehr guter Zustand/ very good, Buch ist eingeschweißt ha1001028 Sprache: Englisch Gewicht in Gramm: 450.

Condizione: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | From our current knowledge, it is obvious that estrogen action in­ volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes­ tinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the spectrum of significant physiological dysfunctions that occur when there is a loss The participants of the workshop VI Preface of the hormone or the receptor activity. Loss of estrogen, however (for instance during menopause), occurs with time and results in a variety of clinical conditions. We know that the developmental loss of estrogen, as seen in clinical cases of aromatase gene mutations and experimental models, has dramatic effects in both men and women alike. The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient. Developing an understanding of the spectrum of estrogen in a variety of tissues related to the condition of estrogen loss is a major and highly active clinical as well as basic scientific research area. Following the discovery of a second estrogen receptor and possible receptor ligand-independent activity as well as the genomic and non­ genomic actions of estrogen, it is clear that the mechanisms of the effects of estrogen are multifaceted.

Condizione: Sehr gut. Zustand: Sehr gut | Seiten: 308 | Sprache: Englisch | Produktart: Bücher | Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov­ ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

Condizione: New. pp. 232.

Condizione: New.

Condizione: New. In.

Paperback. Condizione: Brand New. reprint edition. 232 pages. 8.27x5.83x0.55 inches. In Stock.

Taschenbuch. Condizione: Neu. New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy | Kenneth S. Korach (u. a.) | Taschenbuch | xvi | Englisch | 2012 | Springer | EAN 9783662053881 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - From our current knowledge, it is obvious that estrogen action in volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes tinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the spectrum of significant physiological dysfunctions that occur when there is a loss The participants of the workshop VI Preface of the hormone or the receptor activity. Loss of estrogen, however (for instance during menopause), occurs with time and results in a variety of clinical conditions. We know that the developmental loss of estrogen, as seen in clinical cases of aromatase gene mutations and experimental models, has dramatic effects in both men and women alike. The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient. Developing an understanding of the spectrum of estrogen in a variety of tissues related to the condition of estrogen loss is a major and highly active clinical as well as basic scientific research area. Following the discovery of a second estrogen receptor and possible receptor ligand-independent activity as well as the genomic and non genomic actions of estrogen, it is clear that the mechanisms of the effects of estrogen are multifaceted.

Condizione: New. In.

Condizione: New. In.

Condizione: New.

Condizione: New.

Condizione: New.

Condizione: New. pp. 209.

Condizione: New. pp. 209.

Condizione: New. pp. 310.

Condizione: New. Offers an interdisciplinary view of modern approaches to drug discovery as used by pharmaceutical companies and research institutes. This book comprehensively covers proteomics, bioinformatics, screening techniques such as high-throughput, natural compounds, and NMR-based-screenings, combinatorial chemistry, and compound library design. Editor(s): Hillisch, Alexander; Hilgenfeld, Rolf. Series: Experientia Supplementum. Num Pages: 292 pages, biography. BIC Classification: KNDP; MMG; TDCW. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly. Dimension: 235 x 155 x 21. Weight in Grams: 800. . 2002. Hardback. . . . .

Condizione: New. pp. ix + 292.

Condizione: New. pp. 209.

Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.