Lingua: Inglese
Editore: Singapore, Springer Singapore : Imprint: Springer., 2018
ISBN 10: 9811065462 ISBN 13: 9789811065460
Da: Universitätsbuchhandlung Herta Hold GmbH, Berlin, Germania
Prima edizione
EUR 15,00
Quantità: 1 disponibili
Aggiungi al carrello1st ed. 2018. XV, 114 p. Hardcover. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Springer Theses, Recognizing Outstanding Ph.D. Research. Sprache: Englisch.
Da: Universitätsbuchhandlung Herta Hold GmbH, Berlin, Germania
EUR 19,00
Quantità: 1 disponibili
Aggiungi al carrelloXV, 114 p. Softcover. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Springer Theses. Recognizing Outstanding Ph.D. Research. Sprache: Englisch.
Da: Ria Christie Collections, Uxbridge, Regno Unito
EUR 112,79
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Aggiungi al carrelloCondizione: New. In.
Da: Ria Christie Collections, Uxbridge, Regno Unito
EUR 114,52
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Da: GreatBookPrices, Columbia, MD, U.S.A.
Condizione: New.
Condizione: New. Softcover reprint of the original 1st ed. 2018 edition NO-PA16APR2015-KAP.
Da: moluna, Greven, Germania
EUR 92,27
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Aggiungi al carrelloCondizione: New.
Da: moluna, Greven, Germania
EUR 93,00
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Da: GreatBookPricesUK, Woodford Green, Regno Unito
EUR 136,35
Quantità: 10 disponibili
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Da: Revaluation Books, Exeter, Regno Unito
EUR 147,60
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Aggiungi al carrelloPaperback. Condizione: Brand New. reprint edition. 132 pages. 9.25x6.10x0.30 inches. In Stock.
Da: Revaluation Books, Exeter, Regno Unito
EUR 149,50
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Aggiungi al carrelloHardcover. Condizione: Brand New. 129 pages. 9.25x6.10x0.59 inches. In Stock.
Da: GreatBookPrices, Columbia, MD, U.S.A.
Condizione: As New. Unread book in perfect condition.
Da: California Books, Miami, FL, U.S.A.
EUR 166,03
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Da: preigu, Osnabrück, Germania
EUR 95,15
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Aggiungi al carrelloTaschenbuch. Condizione: Neu. Advancing Development of Synthetic Gene Regulators | With the Power of High-Throughput Sequencing in Chemical Biology | Anandhakumar Chandran | Taschenbuch | Springer Theses | xv | Englisch | 2019 | Springer | EAN 9789811348990 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Da: Majestic Books, Hounslow, Regno Unito
EUR 165,17
Quantità: 3 disponibili
Aggiungi al carrelloCondizione: New.
Da: AHA-BUCH GmbH, Einbeck, Germania
EUR 112,77
Quantità: 2 disponibili
Aggiungi al carrelloBuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book focuses on an 'outside the box' notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)-N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence.
Da: GreatBookPricesUK, Woodford Green, Regno Unito
EUR 159,87
Quantità: 10 disponibili
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Da: THE SAINT BOOKSTORE, Southport, Regno Unito
EUR 164,46
Quantità: 1 disponibili
Aggiungi al carrelloHardback. Condizione: New. New copy - Usually dispatched within 4 working days.
Da: AHA-BUCH GmbH, Einbeck, Germania
EUR 112,77
Quantità: 1 disponibili
Aggiungi al carrelloTaschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book focuses on an 'outside the box' notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)-N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence.
Da: Revaluation Books, Exeter, Regno Unito
EUR 165,64
Quantità: 2 disponibili
Aggiungi al carrelloHardcover. Condizione: Brand New. 310 pages. 9.00x6.00x1.00 inches. In Stock.
Condizione: New. 1st edition NO-PA16APR2015-KAP.
Da: Biblios, Frankfurt am main, HESSE, Germania
EUR 188,28
Quantità: 3 disponibili
Aggiungi al carrelloCondizione: New.
Lingua: Inglese
Editore: Royal Society of Chemistry, 2025
ISBN 10: 183767065X ISBN 13: 9781837670659
Da: Books Puddle, New York, NY, U.S.A.
Condizione: New. 1st edition NO-PA16APR2015-KAP.
Da: GreatBookPrices, Columbia, MD, U.S.A.
EUR 207,68
Quantità: Più di 20 disponibili
Aggiungi al carrelloCondizione: New.
Lingua: Inglese
Editore: Royal Society of Chemistry, 2025
ISBN 10: 183767065X ISBN 13: 9781837670659
Da: Majestic Books, Hounslow, Regno Unito
EUR 209,22
Quantità: 1 disponibili
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Da: Ria Christie Collections, Uxbridge, Regno Unito
EUR 204,39
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Da: GreatBookPricesUK, Woodford Green, Regno Unito
EUR 204,38
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Da: GreatBookPrices, Columbia, MD, U.S.A.
EUR 225,61
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Aggiungi al carrelloCondizione: As New. Unread book in perfect condition.
Da: Revaluation Books, Exeter, Regno Unito
EUR 218,42
Quantità: 2 disponibili
Aggiungi al carrelloHardcover. Condizione: Brand New. 312 pages. 9.18x6.12x9.45 inches. In Stock.
Lingua: Inglese
Editore: Royal Society of Chemistry, 2025
ISBN 10: 183767065X ISBN 13: 9781837670659
Da: Biblios, Frankfurt am main, HESSE, Germania
EUR 213,90
Quantità: 1 disponibili
Aggiungi al carrelloCondizione: New.