Franklin rosalind (25 risultati)

paperback. Condizione: Very Good. Most items will be dispatched the same or the next working day. A copy that has been read, but is in excellent condition. Pages are intact and not marred by notes or highlighting. The spine remains undamaged.

paperback. Condizione: Good. Most items will be dispatched the same or the next working day. A copy that has been read but remains in clean condition. All of the pages are intact and the cover is intact and the spine may show signs of wear. The book may have minor markings which are not specifically mentioned.…

paperback. Condizione: Very Good. Most items will be dispatched the same or the next working day. A copy that has been read, but is in excellent condition. Pages are intact and not marred by notes or highlighting. The spine remains undamaged.

Paperback. Condizione: Good. No Jacket. Pages can have notes/highlighting. Spine may show signs of wear. ~ ThriftBooks: Read More, Spend Less.

Hardback. Condizione: Very Good. The book has been read, but is in excellent condition. Pages are intact and not marred by notes or highlighting. The spine remains undamaged.

Condizione: Good. Pages intact with minimal writing/highlighting. The binding may be loose and creased. Dust jackets/supplements are not included. Stock photo provided. Product includes identifying sticker. Better World Books: Buy Books. Do Good.

Paperback. Condizione: Good. No Jacket. Pages can have notes/highlighting. Spine may show signs of wear. ~ ThriftBooks: Read More, Spend Less.

Condizione: New.

Condizione: New.

Condizione: very_good. Fast Free Shipping â" Very Good condition book with a firm cover and clean pages. Shows normal use and some light wear or limited notes markings. A solid, nice copy to enjoy.

Soft cover. Condizione: Very Good. paperback, 4to, 28pp, colour illustrated, clean and tight, no inscriptions, corners slightly scuffed, small label mark on front cover corner. Very Good condition. ISBN: 1905363087.

Paperback. Condizione: Used; Very Good. **SHIPPED FROM UK** We believe you will be completely satisfied with our quick and reliable service. All orders are dispatched as swiftly as possible! Buy with confidence! Greener Books.

Paperback. Condizione: Used; Good. **SHIPPED FROM UK** We believe you will be completely satisfied with our quick and reliable service. All orders are dispatched as swiftly as possible! Buy with confidence! Greener Books.

Taschenbuch. Condizione: Neu. Neuware.

Condizione: New. pp. 271.

Condizione: New.

Condizione: New. pp. 271.

Condizione: New. pp. 271.

Buch. Condizione: Neu. Neuware.

First edition, the complete journal volume containing the first four papers on the structure of DNA, signed by Crick on the key 'Molecular Structure of Nucleic Acids' paper. From the library of John D. Mollon, eminent professor of visual neuroscience at Cambridge. First edition, complete volume, signed by Crick on the first paper; 8vo (24.5 x 17 cm); illustrations throughout the text, 1982 ownership inscription of J.D. Mollon to front pastedown, spotting to early and late leaves; contemporary green library cloth, titles to spine gilt, red speckled edges, corners bumped and worn, a little wear at the ends of the spine, lower joint just starting, very good condition; 1168pp, 64 page index. …

Hardcover. Condizione: VG+. Volume 171 J.D.Watson and F.H.C. Crick, "Molecular Structure of Nucleic Acids A Structure for Deoxyribose Nucleic Acid", 737 J.D.Watson and F.H.C. Crick, "Genetical Implications of the Structure of Deoxyribonuclei. Quarto. Three volumes, each bound in blue cloth with label to spine. Occasional fingersoiling and pencil marginalia. Light foxing to block edges of Vol. 172. Vol. 171 with inked and embossed stamps of Naval Research Laboratory Library to title page. Tape repair to 1181/82 of Vol. 172. Signed by Crick at first page of each of three articles he co-authored (twice in Vol. 171, once in Vol. 192). Housed in blue cloth slipcase. Vol. 171: [ii], 1168, iii-llxiv. Vol. 172: lxxi, [1], 1200 pp. Vol. 192: cvii, [cviii, blank], xiv-xvi, 50, xvii-xxx, 51-70, xxxi-xxxii, 71-94, lxi-lxiv, 95-112, lxv-lxxx, 113-194, cvii-cxxii, 195-292, clv-clxxii, 293-372, clxxii-clxxiv, 373-386, cciii-ccxxii, 387-484, ccxlvii-cclxv, 485-586, cclxxxix-cccviii, 587-688, cccxxxiii-cccl, 689-784, ccclxxxi-ccccxviii, 785-989, ccccxli-ccccxlviii, 899-1002, cccclxxxiii-dii, 1003-1104, dxxi-dxxxii, 1105-1218, dliii-dlxxii, 1219-1322 Volume 171 J.D.Watson and F.H.C. Crick, "Molecular Structure of Nucleic Acids A Structure for Deoxyribose Nucleic Acid", 737 J.D.Watson and F.H.C. Crick, "Genetical Implications of the Structure of Deoxyribonucleic Acid", 964 Rosalind E. Franklin and R. G. Gosling, "Molecular Structure of Nucleic Acids Molecular Configuration in Sodium Thrymonucleate", 740 M.H.F. Wilkins, A.R. Stokes & H.R. Wilson, "Molecular Structure of Deoxypentose Nucleic Acids", 738 Volume 172 Rosalind E. Franklin and R. G. Gosling, "Evidence for 2-Chain Helix in Crystalline Structure of Sodium Deoxyribonucleate", 156 M.H.F. Wilkins, W.E. Seeds & A. R. Stokes, H.R. Wilson, "Helical Structure of Crystalline Deoxypentose Nucleic Acid", 759 Volume 192 F.H.C. Crick, Leslie Barnett, S. Brenner, R.J. Watts-Tobin, "General Nature of the Genetic Code for Proteins", 1227. Book.…

First edition. The Molecule That Copies Itself. First edition, in the rare three-paper offprint issue - the author's separate that gathers the whole of the 25 April 1953 Nature announcement - of the discovery of the molecular structure of DNA, the double helix, and with it the mechanism by which living things copy their inheritance. The journal's printer reset the three papers of that issue into a single pamphlet for the authors to send to colleagues. This three-paper offprint is far scarcer than the journal itself. Watson and Crick conducted no experiments of their own. Working at the Cavendish Laboratory in Cambridge across eighteen months, they unified the scattered findings of others into a single structure - two helical sugar-phosphate chains wound about a common axis, running in opposite directions, with the four bases paired across the inside of the ladder. The pairing was the whole of it: adenine always to thymine, cytosine always to guanine, so that the sequence of one strand fixes the sequence of the other. From that single constraint followed the answer to the oldest question in biology - how a gene is copied, with near-perfect fidelity, generation upon generation. The structure the paper sets out is exact and spare. Two right-handed helical chains coil about a common axis, the sugar-phosphate backbones on the outside and the paired bases stacked flat within, perpendicular to the axis; a residue recurs every 3.4 ångström along each chain, the helix repeats after ten residues at intervals of 34 ångström, and the whole forms a cylinder some twenty ångström across. Because the phosphates face outward into the surrounding water, solvent and cations reach them freely, and the model so accounts for the high water content of the fibres that Franklin had measured. Crick's lone schematic - two ribbons winding about a vertical fibre axis, the base-pairs drawn as horizontal rods between them - expresses the entire proposal in a single figure; it is this drawing, since become one of the most reproduced diagrams in modern science, that fills the second page of the present pamphlet. Everything the structure asserts is checked against the X-ray evidence: the perpendicular bases, the regular backbones, the antiparallel chains, each a feature the diffraction pattern demanded rather than a freedom the model-builders allowed themselves. The problem they solved was eighty years in the making. In 1869 the Swiss physiological chemist Friedrich Miescher, washing the pus from used surgical bandages to isolate the proteins of white blood cells, instead struck a substance from the cell nucleus richer in phosphorus than any protein and resistant to protein digestion; he named it nuclein and guessed that a whole family of such molecules might exist. The guess was forgotten. By the early 1950s researchers spoke confidently of the gene as the unit of heredity yet could not say what one looked like or how it was copied. Oswald Avery had shown in 1944 that it was DNA, not protein, that carried hereditary character in pneumococcus, but many held the molecule too monotonous - a backbone of four repeating units - to encode the intricacy of a living thing; the genetic material, they reasoned, surely had to be protein, with its twenty amino acids and endless variety. Crick and Watson grasped early that the three-dimensional shape of the gene was the central problem of the new biology, and that without it heredity could not be understood. They seized it at their first meeting, in 1951, and held to it with a single-mindedness that required them to absorb genetics, biochemistry, physical chemistry, and X-ray crystallography at once. Several disconnected results lay waiting to be joined. Alexander Todd had established that the molecular backbone was a regular chain of alternating phosphate and deoxyribose sugar. Erwin Chargaff had found that, however widely the proportions of the four bases varied between species, adenine and thymine always occurred in equal amounts, as.…

First Edition. WATSON, James; CRICK, Francis; WILKINS, M.H.F; FRANKLIN, Rosalind; et al. "A Structure for Deoxyribose Nucleic Acid" (171: 737-38); WITH: "Molecular Structure of Deoxypentose Nucleic Acids" (171:738-40); WITH: "Molecular Configuration in Sodium Thymonucleate" (171: 740-41); WITH: "Genetical Implications of the Structure of Deoxyribonucleic Acid" (171: 964-67); WITH: "Evidence for 2-Chain Helix in Crystalline Structure of Sodium Deoxyribonucleate" (172: 156-57); WITH: "Heterogeneity of Deoxyribonucleic Acids" (172: 339-42). FROM: Nature: A Weekly Journal of Science, Volumes 171 and 172, January 3, 1953 to December 26, 1953. London: Macmillan and Co., (1953). Thin octavo, disbound, modern stiff paper wrappers. $8800.Six articles extracted from Volumes 171 and 172 of Nature, including the first appearance of the article announcing the most important biological discovery of the 20th century, as well as five follow-up articles further establishing the structure and function of DNA. In these articles in the journal Nature, the most important biological discovery of the 20th century is calmly announced and concisely elucidated in a paper little more than a page long: the key to the deciphering of the genetic code. "It has not escaped our notice," write Watson and Crick near the end of the first paper, "that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material." Neither did it escape the notice of the Nobel Prize committee. In 1962 Crick, Watson and Wilkins received the Nobel Prize in Medicine "for their discoveries concerning the molecular structure of nuclear acids and its significance for information transfer in living material" (Garrison & Morton 256.3; 256.4). Rosalind Franklin mayÑand surely shouldÑhave been included in the award as well were it not for her early death in 1958. These papers document the birth of a new science, Molecular Biology, whose benefits for humanity we are only now beginning to realize. Dibner 200. Grolier Club, One Hundred Books Famous in Medicine, 99. Garrison & Morton 256.3, 256.4. Closely bound, with tight inner margins. Text fine. …

First edition, the three-paper offprint issue, of the primary record of the co-discovery of the molecular structure of DNA. This copy is from the library of Professor Hans Gustav Boman (1924-2008), the leading molecular biologist in Sweden; his signature is in ink on the first page. Three research groups independently investigated the structure of DNA in England in the early 1950s: Francis Crick and James Watson at the Cavendish Laboratory in Cambridge and two teams at King's College, London comprising Maurice Wilkins, Rosalind Franklin, Raymond Gosling, Alec Stokes, and Herbert Wilson. To acknowledge the simultaneity of the discovery, the directors of the respective institutions agreed that the three resulting papers would be published under the general title Molecular Structure of Nucleic Acids in the British scientific weekly Nature. Crick and Watson's paper, "A Structure for Deoxyribose Nucleic Acid", is illustrated with a schematic drawing by Odile Crick of the twisted-ladder structure of DNA, now famously known as the double helix. Wilkins, Stokes, and Wilson co-wrote "Molecular Structure of Deoxypentose Nucleic Acids", the second paper. Franklin and her research student Gosling submitted "Molecular Configuration in Sodium Thymonucleate", which features a halftone illustration of Gosling's iconic X-ray "Photograph 51" of crystallized DNA. Franklin died four years before the Nobel Prize in Physiology or Medicine was awarded to Crick, Watson, and Wilkins in 1962 for their work on DNA, but without question her "contributions, and indeed her actual X-ray data, were crucial to the total achievement" (ODNB). "Two offprints exist of Watson and Crick's paper: a single sheet containing the Watson and Crick article only, and a fourteen-page pamphlet containing the papers of all three research groups. The pamphlet pages are smaller in size than the single leaf, which has the same dimensions as the leaves of the journal, and the layout is different, the single-leaf offprint being printed in two columns like the journal, the pamphlet in single-column pages. The page breaks are different in each of the two offprints and the journal, as is the placement of the illustrations relative to the text. Despite these differences, all three versions appear to have been printed from the same setting of type, except that in the two offprints one paragraph of text has been reset to accommodate the placement of the diagram of the DNA molecule" (Grolier, p. 363). Haskell F. Norman discusses the difficulty in establishing priority between the two formats in his introduction to One Hundred Books Famous in Medicine and closes by stating that "it is now our tentative conclusion that the three-paper offprint is the first issue" (p. xxi). Boman "was one of the pioneers in the field of molecular biology in Sweden" (Norrby, p. 11). After teaching at Uppsala University he transferred to Umeå University to establish their microbiology department; under his leadership it became an international hub of research excellence. "Halfway through his career Boman moved on to Stockholm University and initiated a completely new line of research. It pioneered the development of insights into the emerging field of natural immunity. He developed this work in collaboration with Swedish colleagues and coined the term cecropines for this new kind of peptide antibiotics. This was a Nobel-class discovery" but - like Franklin - Boman died before he could see his research recognized as such (Norrby, p. 11). In 2011, his work formed the basis of a discovery by Jules Hoffman and Bruce Beutler, for which they received the Nobel Prize in Physiology or Medicine. Garrison-Morton 256.3 (Crick and Watson's paper); Grolier, One Hundred Books Famous in Medicine, 99; Heirs of Hippocrates 2342. Erling Norrby, Nobel Prizes: Cancer, Vision and the Genetic Code, 2019. Octavo, pp. 14. With 4 illustrations. Printed pamphlet, wire-stitched as issued. A few neat red pencil marks to first three pages, lower outer corners creased: a near-fine copy.…

Two bound volumes. Volume 171 (January 3 1953 to June 27 1953) and Volume 172 (July 4 1953 to December 22 1953). Bound in maroon (vol. 171) and brick-red (vol. 172) cloth, spine lettered in gilt. In very good condition. Front pastedown has the bookplate of Worthing Public Library and title page of volume 172 (and verso of volume 171) has a small round Worthing Public Library stamp. The papers are as follows: 1. Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid, by J.D.Watson and F.H.C. Crick. Nature, Volume 171, No. 4356. April 25 1953. pp737-738. 2. Molecular Structure of Deoxypentose Nucleic Acids, by M.H.F. Wilkins, A.R.Stokes and H.R.Wilson Nature, Volume 171, No. 4356. April 25 1953. pp738-740. 3. Molecular configuration in Sodium Thymonucleate by Rosalind E. Franklin and R.G.Gosling. Nature, Volume 171, No. 4356. April 25 1953. pp740-741. 4. Genetical Implications of the Structure of Deoxyribonucleic Acid by J.D.Watson and F.H.C.Crick. Nature, Volume 171, No. 4361. May 30 1953. pp964-967. 5. Evidence for 2-Chain Helix in Crystalline Structure of Sodium Deoxyribonucleate by Rosalind E. Franklin and R.G.Gosling. Nature, Volume 172, No. 4369, July 25 1953. pp156-157. 6. Helical Structure of Crystalline Deoxypentose Nucleic Acid, by M.H.F.Wilkins, W.E.Seeds, A.R.Stokes and H.R.Wilson. Nature, Volume 172, No. 4382, October 24 1953. pp759-762. Together these papers, announcing the discovery of DNA, provide the single most important advance in biology since Darwin's theories. Although Crick and Watson are the best known of the scientists working on the structure of deoxyribose nucleic acid (DNA) it was a collaborative venture and it is now recognised that the model used by Watson and Crick was based almost completely on the findings of Rosalind Franklin and Maurice Wilkins.…