jerry b hook (24 risultati)

Condizione: Good. [ No Hassle 30 Day Returns ][ Ships Daily ] [ Underlining/Highlighting: NONE ] [ Writing: NONE ] [ Edition: Reprint ] Publisher: Plenum Pub Date: 1/1/1990 Binding: Hardcover Pages: 489 Reprint edition.

Hardcover. Condizione: Very Good. Series: New Horizons in Therapeutics xxii 488p hardback with green laminated boards, fresh clean copy, library stamp, very good indeed Language: English.

Condizione: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,950grams, ISBN:0306434636.

Hardcover. Condizione: Good. No Jacket. 0881678856. Red cloth Pictorial board hardcover, with bright gold lettering on the spine and front board, from closed pharmaceutical company library. 572 pages, index, illustrated with photos, charts, tables and diagrams. Contents clean, tight and bright. Book.

Hardcover. Condizione: Very Good. 8vo, hardcover. No dj, black cloth. Vg+ condition. Board corners slightly bumped; contents bright & clean, binding tight. xiv, 488 p.

Hardcover. Condizione: Good. No Jacket. First Edition. From an academic library with the usual stamps and labels. Apart from the library providence and some light general wear, a clean tight copy. One of the series New Horizons in Therapeautics. This is a heavy book and we will request extra postage if ordered from outside the UK. A00002587.

Condizione: New.

Hardcover. Red cloth, gold lettering, no dj, vg condition. Medical; 9441.

hardcover. Condizione: Very Good. Condizione sovraccoperta: No Dust Jacket. Second Edition. numerous figures and tables, gilt lettering to spine and front cover, lightly rubbed tail of spine, text clean and tight. Ex-Library.

Condizione: New. In.

Paperback. Condizione: Brand New. reprint edition. 534 pages. 9.02x5.98x1.17 inches. In Stock.

Taschenbuch. Condizione: Neu. Protein Design and the Development of New Therapeutics and Vaccines | Jerry B. Hook (u. a.) | Taschenbuch | xxii | Englisch | 2012 | Springer | EAN 9781468457414 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - InhaltsangabeI. Advances in the Structural Analysis of Proteins.- 1 Dynamic Processes in Proteins by X-Ray Diffraction.- 1. Dynamic Processes in Proteins.- 2. Enzyme Substrate Complexes by X-Ray Diffraction.- 3. Laue Diffraction.- 4. Reaction Synchronization.- References.- 2 Mass Spectrometric Methods for Determination of the Structure of Peptides and Proteins.- 1. Introduction.- 2. High-Mass Mass Spectrometry.- 3. Tandem Mass Spectrometry.- 3.1. Sequencing of Proteins.- 3.2. Increasing Sensitivity by Using an Array Detector.- 3.3. Computer-Aided Interpretation of CID Spectra of Peptides.- 4. Conclusion.- References.- II. Protein Folding and Stability.- 3 Protein Folding and Stability.- 1. Goals.- 2. Folding of Fragments.- 3. Trapping Folding Intermediates.- References.- 4 Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo.- 1. Introduction.- 2. The Protein Folding Grammar.- 3. Intracellular Intermediates in Chain Folding and Assembly.- 4. Temperature-Sensitive Folding Mutations.- 5. Nonsense Mutations.- 6. Intracellular Aggregation and Inclusion Body Formation.- 7. Kinetics of Aggregate Formation.- 8. Isolation of Second-Site Suppressors of Folding Mutants.- 9. The Suppressing Amino Acid Substitutions Act at the Level of Polypeptide Chain Maturation.- 10. The Suppressors Act in the Folding of the Single Chain, Not during Chain-Chain Association.- 11. The Suppressors Increase the Efficiency of Folding of the Wild-Type Chain.- References.- 5 Unfolding and Inactivation: Genetic and Chemical Approaches to the Stabilization of T4 Lysozyme and Human Interferon Gamma against Irreversible Thermal Denaturation.- 1. Introduction.- 2. T4 Lysozyme.- 2.1. Sulfhydryl Oxidation.- 2.2. Thiol/Disulfide Interchange.- 2.3. Adsorption.- 2.4. Aggregation.- 2.5. Chemical Inactivation.- 2.6. Conclusions from T4 Lysozyme Experiments.- 3. Interferon- .- 3.1. In Vitro Experiments.- 3.2. Genetic Experiments.- 4. General Conclusions.- 4.1. Modes of Thermal-Irreversible Denaturation.- 4.2. Strategies for Stabilizing Proteins.- References.- III. Principles of Receptor Design and Regulation.- 6 Protein-Tyrosine Kinases and Their Substrates: Old Friends and New Faces.- 1. Introduction.- 2. Isolation of Novel Protein-Tyrosine Kinases.- 3. Regulation of Protein-Tyrosine Kinase Activity: Phosphorylation of pp60c-src.- 4. Protein-Tyrosine Kinase Substrates.- References.- IV. The Guanine Nucleotide Binding Protein Family.- 7 G Proteins: A Family of Signal-Transducing Molecules.- 1. The Family of G Proteins.- 2. Distribution of G Protein Subunits.- 3. Regulation of o Levels.- 4. G Proteins as Bifurcating Signals.- 5. Organizing Principles.- References.- 8 Model of Signal Transduction by G Proteins: Roles of a Subunits and Dimers in Regulation of Ionic Channels and Adenylyl Cyclase.- 1. Introduction.- 2. Mechanisms of Receptor-Mediated Activation of G Proteins.- 3. Which G-Protein Subunit Mediates the Effect of Receptors .- 3.1. Regulation of Ionic Channels: or , and What Does Each Do to Regulation of Channel Activity .- 3.2. Inhibitory Regulation of Adenylyl Cyclase: i or .- 3.3. What Is the Role of Dimers .- References.- 9 Structural Homologies in G-Binding Proteins.- 1. Introduction.- 2. Structural Homology in Three Dimensions.- 2.1. Elongation Factor Tu (EF-Tu).- 2.2. ras Protein p21.- 3. Sequence Homology.- 3.1. Overall Homology.- 3.2. Consensus Sequences.- 4. Homology and Functional Similarity.- References.- V. Modeling and Structure Prediction in Macromolecules.- 10 Knowledge-Based Protein Modeling and the Design of Novel Molecules.- 1. Introduction.- 2. Learning by Comparison of Structures.- 2.1. Superposition of Structures.- 2.2. Comparison of Properties and Relations.- 2.3. Clustering and Tree Construction.- 3. Rules for Tertiary Templates and Key Residues, and Their Comparison with a Sequence of an Unknown.- 3.1 Consensus Sequences for Framework Regions.- 3.2. Key Residues from Compa.

Paperback. Condizione: Like New. Like New. book.

Condizione: As New. Unread book in perfect condition.

Condizione: As New. Unread book in perfect condition.

Condizione: As New. Unread book in perfect condition.

Condizione: New.

Condizione: New.

Second edition. orig. cloth Minor rubbing.Small label to rear cover.Light page-edge soil.VG. Textual photos & tables. 24x16cm, xiii,558 pp, Series: Target Organ Toxicology Series. Contains 19 papers. Includes: L.B. Kinter & B.G. Short "Anatomy and Physiology of the Kidney: A Brief Review"; E.C. Foulkes "Functional Assessment of the Kidney"; W.M. Bennet & G.A. Porter "Overview of Clinical Nephrotoxicity"; S. Olsen & K. Solez "Morphological Features of Acute Renal Failure"; M. Brezis & F.H. Epstein "Pathophysiology of Acute Renal Failure"; M. Abbate; D. Macconi & G. Remuzzi "Mechanisms of Glomerular Injury"; R.S. Goldstein "Biochemical Heterogeneity and Site-Specific Tubular Injury"; J.J. Weening "Nephrotoxicity of Protein Overloading"; B.M.Tune "The Nephrotoxicity of Beta-Lactam Antibiotics"; R.F. Borch "The Nephrotoxicity of Antineoplastic Drugs"; G.F. Duggin "Analgesic Nephrotoxicity"; L.C. Racusen & K. Solez "Nephrotoxicity of Cylosporine and Other Immunosuppressive and Immunotherapeutic Agents"; G.L. Bakris Pathogenesis and Therapeutic Aspects of Radiocontrast-Induced Renal Dysfunction"; A.A. Elfarra "Aliphatic Halogenated Hydrocarbons"; S.S. Lau &T.J. Monks "Nephrotoxicity of Bromobenzene: The Role of Quinone- Thioethers"; E.A: Conner & B.A. Fowler "Mechanisms of Metal-Induced Nephrotoxicity"; W.O. Berndt "Effects of Selected Fungal Toxins on Renal Function"; L.D. Lehman-McKeeman "Male Rat-Specific Light Hydrocarbon Nephropathy"; D.R. Dietrich & J.A. Swenberg "Renal Carcinogenesis". Minor rubbing.Small label to rear cover.Light page-edge soil.VG.

Condizione: new. Questo è un articolo print on demand.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -InhaltsangabeI. Advances in the Structural Analysis of Proteins.- 1 Dynamic Processes in Proteins by X-Ray Diffraction.- 1. Dynamic Processes in Proteins.- 2. Enzyme Substrate Complexes by X-Ray Diffraction.- 3. Laue Diffraction.- 4. Reaction Synchronization.- References.- 2 Mass Spectrometric Methods for Determination of the Structure of Peptides and Proteins.- 1. Introduction.- 2. High-Mass Mass Spectrometry.- 3. Tandem Mass Spectrometry.- 3.1. Sequencing of Proteins.- 3.2. Increasing Sensitivity by Using an Array Detector.- 3.3. Computer-Aided Interpretation of CID Spectra of Peptides.- 4. Conclusion.- References.- II. Protein Folding and Stability.- 3 Protein Folding and Stability.- 1. Goals.- 2. Folding of Fragments.- 3. Trapping Folding Intermediates.- References.- 4 Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo.- 1. Introduction.- 2. The Protein Folding Grammar.- 3. Intracellular Intermediates in Chain Folding and Assembly.- 4. Temperature-Sensitive Folding Mutations.- 5. Nonsense Mutations.- 6. Intracellular Aggregation and Inclusion Body Formation.- 7. Kinetics of Aggregate Formation.- 8. Isolation of Second-Site Suppressors of Folding Mutants.- 9. The Suppressing Amino Acid Substitutions Act at the Level of Polypeptide Chain Maturation.- 10. The Suppressors Act in the Folding of the Single Chain, Not during Chain-Chain Association.- 11. The Suppressors Increase the Efficiency of Folding of the Wild-Type Chain.- References.- 5 Unfolding and Inactivation: Genetic and Chemical Approaches to the Stabilization of T4 Lysozyme and Human Interferon Gamma against Irreversible Thermal Denaturation.- 1. Introduction.- 2. T4 Lysozyme.- 2.1. Sulfhydryl Oxidation.- 2.2. Thiol/Disulfide Interchange.- 2.3. Adsorption.- 2.4. Aggregation.- 2.5. Chemical Inactivation.- 2.6. Conclusions from T4 Lysozyme Experiments.- 3. Interferon- .- 3.1. In Vitro Experiments.- 3.2. Genetic Experiments.- 4. General Conclusions.- 4.1. Modes of Thermal-Irreversible Denaturation.- 4.2. Strategies for Stabilizing Proteins.- References.- III. Principles of Receptor Design and Regulation.- 6 Protein-Tyrosine Kinases and Their Substrates: Old Friends and New Faces.- 1. Introduction.- 2. Isolation of Novel Protein-Tyrosine Kinases.- 3. Regulation of Protein-Tyrosine Kinase Activity: Phosphorylation of pp60c-src.- 4. Protein-Tyrosine Kinase Substrates.- References.- IV. The Guanine Nucleotide Binding Protein Family.- 7 G Proteins: A Family of Signal-Transducing Molecules.- 1. The Family of G Proteins.- 2. Distribution of G Protein Subunits.- 3. Regulation of o Levels.- 4. G Proteins as Bifurcating Signals.- 5. Organizing Principles.- References.- 8 Model of Signal Transduction by G Proteins: Roles of a Subunits and Dimers in Regulation of Ionic Channels and Adenylyl Cyclase.- 1. Introduction.- 2. Mechanisms of Receptor-Mediated Activation of G Proteins.- 3. Which G-Protein Subunit Mediates the Effect of Receptors .- 3.1. Regulation of Ionic Channels: or , and What Does Each Do to Regulation of Channel Activity .- 3.2. Inhibitory Regulation of Adenylyl Cyclase: i or .- 3.3. What Is the Role of Dimers .- References.- 9 Structural Homologies in G-Binding Proteins.- 1. Introduction.- 2. Structural Homology in Three Dimensions.- 2.1. Elongation Factor Tu (EF-Tu).- 2.2. ras Protein p21.- 3. Sequence Homology.- 3.1. Overall Homology.- 3.2. Consensus Sequences.- 4. Homology and Functional Similarity.- References.- V. Modeling and Structure Prediction in Macromolecules.- 10 Knowledge-Based Protein Modeling and the Design of Novel Molecules.- 1. Introduction.- 2. Learning by Comparison of Structures.- 2.1. Superposition of Structures.- 2.2. Comparison of Properties and Relations.- 2.3. Clustering and Tree Construction.- 3. Rules for Tertiary Templates and Key Residues, and Their Comparison with a Sequence of an Unknown.- 3.1 Consensus Sequences for Framework Regions.- 3.2. Key Res.

Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. I. Advances in the Structural Analysis of Proteins.- 1 Dynamic Processes in Proteins by X-Ray Diffraction.- 1. Dynamic Processes in Proteins.- 2. Enzyme Substrate Complexes by X-Ray Diffraction.- 3. Laue Diffraction.- 4. Reaction Synchronization.- Reference.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -I. Advances in the Structural Analysis of Proteins.- 1 Dynamic Processes in Proteins by X-Ray Diffraction.- 2 Mass Spectrometric Methods for Determination of the Structure of Peptides and Proteins.- II. Protein Folding and Stability.- 3 Protein Folding and Stability.- 4 Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo.- 5 Unfolding and Inactivation: Genetic and Chemical Approaches to the Stabilization of T4 Lysozyme and Human Interferon Gamma against Irreversible Thermal Denaturation.- III. Principles of Receptor Design and Regulation.- 6 Protein-Tyrosine Kinases and Their Substrates: Old Friends and New Faces.- IV. The Guanine Nucleotide Binding Protein Family.- 7 G Proteins: A Family of Signal-Transducing Molecules.- 8 Model of Signal Transduction by G Proteins: Roles of a Subunits and Dimers in Regulation of Ionic Channels and Adenylyl Cyclase.- 9 Structural Homologies in G-Binding Proteins.- V. Modeling and Structure Prediction in Macromolecules.- 10 Knowledge-Based Protein Modeling and the Design of Novel Molecules.- 11 Computer Simulation Methods as Applied to Site-Specific Mutations.- 12 Dihydrofolate Reductase: A Paradigm for Drug Design.- VI. Protein Engineering and Enzyme Design.- 13 Chemical Approaches to Protein Engineering.- 14 New Engineered Proteins for Use in Therapy and Vaccine Design.- 15 Receptor-Based Design of Dihydrofolate Reductase Inhibitors.- VII. Macromolecules and Targeted Drug Delivery.- 16 Control of the Biological Dispersion of Therapeutic Proteins.- 17 Antibody-Mediated Drug Delivery.- 18 Semisynthetic Catalytic Antibodies.- VIII. Strategies for Directed Mutagenesis of Proteins.- 19 Engineering Novel, Prolonged-Acting Insulins.- IX. Design of Novel Antiviral Agents and Vaccines.- 20 Studies on the Structure andFunction of Ubiquitin.- 21 Recognition at Membrane Surfaces: Influenza HA and Human HLA.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 516 pp. Englisch.